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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

Overview of attention for article published in Frontiers in Physiology, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
2 news outlets
twitter
9 X users
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

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279 Dimensions

Readers on

mendeley
282 Mendeley
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Title
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00354
Pubmed ID
Authors

Calvin R. Justus, Lixue Dong, Li V. Yang

Abstract

The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic evolution. Acidic pH has pleiotropic effects on the proliferation, migration, invasion, metastasis, and therapeutic response of cancer cells and the function of immune cells, vascular cells, and other stromal cells. However, the molecular mechanisms by which cancer cells and stromal cells sense and respond to acidic pH in the tumor microenvironment are poorly understood. In this article the role of a family of pH-sensing G protein-coupled receptors (GPCRs) in tumor biology is reviewed. Recent studies show that the pH-sensing GPCRs, including GPR4, GPR65 (TDAG8), GPR68 (OGR1), and GPR132 (G2A), regulate cancer cell metastasis and proliferation, immune cell function, inflammation, and blood vessel formation. Activation of the proton-sensing GPCRs by acidosis transduces multiple downstream G protein signaling pathways. Since GPCRs are major drug targets, small molecule modulators of the pH-sensing GPCRs are being actively developed and evaluated. Research on the pH-sensing GPCRs will continue to provide important insights into the molecular interaction between tumor and its acidic microenvironment and may identify new targets for cancer therapy and chemoprevention.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Chile 1 <1%
India 1 <1%
Italy 1 <1%
Unknown 278 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 51 18%
Student > Bachelor 42 15%
Researcher 30 11%
Student > Master 30 11%
Student > Doctoral Student 22 8%
Other 46 16%
Unknown 61 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 65 23%
Agricultural and Biological Sciences 43 15%
Medicine and Dentistry 23 8%
Chemistry 21 7%
Pharmacology, Toxicology and Pharmaceutical Science 19 7%
Other 40 14%
Unknown 71 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2024.
All research outputs
#1,563,245
of 25,885,333 outputs
Outputs from Frontiers in Physiology
#862
of 15,739 outputs
Outputs of similar age
#13,442
of 291,617 outputs
Outputs of similar age from Frontiers in Physiology
#25
of 399 outputs
Altmetric has tracked 25,885,333 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,739 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,617 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.