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Effect of intracellular loop 3 on intrinsic dynamics of human β2-adrenergic receptor

Overview of attention for article published in BMC Structural Biology, January 2013
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  • Among the highest-scoring outputs from this source (#41 of 113)
  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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2 tweeters

Citations

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12 Dimensions

Readers on

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33 Mendeley
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1 CiteULike
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Title
Effect of intracellular loop 3 on intrinsic dynamics of human β2-adrenergic receptor
Published in
BMC Structural Biology, January 2013
DOI 10.1186/1472-6807-13-29
Pubmed ID
Authors

Ozer Ozcan, Arzu Uyar, Pemra Doruker, Ebru Akten

Abstract

To understand the effect of the long intracellular loop 3 (ICL3) on the intrinsic dynamics of human β2-adrenergic receptor, molecular dynamics (MD) simulations were performed on two different models, both of which were based on the inactive crystal structure in complex with carazolol (after removal of carazolol and T4-lysozyme). In the so-called loop model, the ICL3 region that is missing in available crystal structures was modeled as an unstructured loop of 32-residues length, whereas in the clipped model, the two open ends were covalently bonded to each other. The latter model without ICL3 was taken as a reference, which has also been commonly used in recent computational studies. Each model was embedded into POPC bilayer membrane with explicit water and subjected to a 1 μs molecular dynamics (MD) simulation at 310 K.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 36%
Student > Master 6 18%
Researcher 5 15%
Unspecified 3 9%
Student > Doctoral Student 2 6%
Other 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 18%
Unspecified 6 18%
Chemistry 6 18%
Agricultural and Biological Sciences 5 15%
Physics and Astronomy 3 9%
Other 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2014.
All research outputs
#2,097,095
of 4,171,124 outputs
Outputs from BMC Structural Biology
#41
of 113 outputs
Outputs of similar age
#52,431
of 118,579 outputs
Outputs of similar age from BMC Structural Biology
#4
of 8 outputs
Altmetric has tracked 4,171,124 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 113 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.