Title |
Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, December 2013
|
DOI | 10.2147/ndt.s53386 |
Pubmed ID | |
Authors |
Hideyuki Shimizu, Minoru Takebayashi, Masayuki Tani, Hiroaki Tanaka, Bun Yamagata, Kenzo Kurosawa, Hiroki Yamada, Mitsugu Hachisu, Kazue Hisaoka-Nakashima, Mami Okada-Tsuchioka, Masaru Mimura, Akira Iwanami |
Abstract |
Recently, the sigma-1 receptor has been shown to play a significant role in the neural transmission of mood by regulating N-methyl-D-aspartate receptors. Additionally, the sigma-1 receptor has been reported to influence cognitive functions including learning and memory. In this study, we measured plasma sigma-1 receptor concentrations before and after antidepressant treatment in patients with late-life major depressive disorder (MDD) and explored whether changes in depressive status are related to sigma-1 receptor concentrations. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 3 | 13% |
Researcher | 3 | 13% |
Student > Bachelor | 3 | 13% |
Other | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Other | 2 | 9% |
Unknown | 8 | 35% |
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Psychology | 7 | 30% |
Medicine and Dentistry | 4 | 17% |
Agricultural and Biological Sciences | 2 | 9% |
Neuroscience | 1 | 4% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 35% |