Title |
Circulating unmethylated insulin DNA as a potential non-invasive biomarker of beta cell death in type 1 Diabetes: a review and future prospect
|
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Published in |
Clinical Epigenetics, April 2017
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DOI | 10.1186/s13148-017-0343-5 |
Pubmed ID | |
Authors |
Kuo Zhang, Guigao Lin, Yanxi Han, Jiehong Xie, Jinming Li |
Abstract |
The early detection of type 1 diabetes (T1D) largely depends on a reliable approach to monitor β cell loss. An effective way to evaluate the decline of β cell mass would allow early preventative intervention to preserve insulin secretion. Recent progress in the development of novel biomarkers, based on tissue-specific methylation patterns, has inspired relevant studies in T1D. In this review, we focus on the application of circulating β cell-derived unmethylated insulin (INS) DNA. Circulating β cell-derived unmethylated INS DNA has a potential clinical value for the early detection of T1D, surveillance of islet transplantation rejection, and evaluation of response to therapy. Utilizing differentiated methylation patterns in different organs and employing a wide variety of molecular technologies also provide insights into the interrogation of biomarkers in other diseases with massive tissue-specific cell loss. Circulating unmethylated INS DNA is a promising molecular biomarker for the early detection of T1D. |
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Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Student > Bachelor | 10 | 16% |
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