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The heterogeneity of cancer stem-like cells at the invasive front

Overview of attention for article published in Cancer Cell International, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 422)
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

1 news outlet


23 Dimensions

Readers on

22 Mendeley
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The heterogeneity of cancer stem-like cells at the invasive front
Published in
Cancer Cell International, February 2017
DOI 10.1186/s12935-017-0393-y
Pubmed ID

Go J. Yoshida


Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid malignant tumors which highly express CD44v8-10, the variant isoform of CD44 generated by alternative splicing, has a resistance to redox stress by the robust production of glutathione mediated by ESRP1-CD44v-xCT (cystine/glutamate antiporter) axis. It has been reported that CD44v and c-Myc tend to show the inversed expression pattern at the invasive front of the aggressive tumors. Given that the accumulation of reactive oxygen species triggers the activation of Wnt/β-catenin signal pathway, it is hypothesized that CD44v causes the negative feedback machinery in the regulation of c-Myc expression via the attenuated ROS-induced Wnt signal pathway. To address the fundamental question whether and how both proliferative and quiescent cancer stem-like cells heterogeneously exist at the invasive/metastatic edge, researchers need to investigate into the E3-ubiquitin ligase activity essential for c-Myc degradation. CSCs heterogeneity at the invasive/metastatic front is expected to demonstrate the dynamic tumor evolution with the selective pressure of anti-cancer treatments. Furthermore, the novel molecular targeting therapeutic strategies would be established to disrupt the finely-regulated c-Myc expression in the heterogeneous CSC population in combination with the typical drug-repositioning with xCT inhibitor.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 36%
Researcher 6 27%
Student > Bachelor 3 14%
Student > Postgraduate 2 9%
Student > Master 1 5%
Other 0 0%
Unknown 2 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 32%
Agricultural and Biological Sciences 6 27%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Business, Management and Accounting 1 5%
Immunology and Microbiology 1 5%
Other 3 14%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2017.
All research outputs
of 11,788,552 outputs
Outputs from Cancer Cell International
of 422 outputs
Outputs of similar age
of 266,294 outputs
Outputs of similar age from Cancer Cell International
of 7 outputs
Altmetric has tracked 11,788,552 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 422 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,294 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them