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The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data

Overview of attention for article published in Genome Biology, September 2007
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1 Google+ user

Citations

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62 Mendeley
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Title
The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data
Published in
Genome Biology, September 2007
DOI 10.1186/gb-2007-8-9-r187
Pubmed ID
Authors

Gabriel S Eichler, Mark Reimers, David Kane, John N Weinstein

Abstract

Interpretation of microarray data remains a challenge, and most methods fail to consider the complex, nonlinear regulation of gene expression. To address that limitation, we introduce Learner of Functional Enrichment (LeFE), a statistical/machine learning algorithm based on Random Forest, and demonstrate it on several diverse datasets: smoker/never smoker, breast cancer classification, and cancer drug sensitivity. We also compare it with previously published algorithms, including Gene Set Enrichment Analysis. LeFE regularly identifies statistically significant functional themes consistent with known biology.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 6%
Israel 1 2%
Netherlands 1 2%
Sweden 1 2%
Unknown 55 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 29%
Student > Ph. D. Student 10 16%
Professor > Associate Professor 9 15%
Professor 6 10%
Student > Master 4 6%
Other 6 10%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 39%
Medicine and Dentistry 9 15%
Computer Science 7 11%
Biochemistry, Genetics and Molecular Biology 3 5%
Mathematics 2 3%
Other 7 11%
Unknown 10 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#16,048,009
of 25,374,917 outputs
Outputs from Genome Biology
#4,001
of 4,467 outputs
Outputs of similar age
#70,570
of 82,438 outputs
Outputs of similar age from Genome Biology
#34
of 40 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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