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Subclinical Diabetes

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2017
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Title
Subclinical Diabetes
Published in
Anais da Academia Brasileira de Ciências, May 2017
DOI 10.1590/0001-3765201720160394
Pubmed ID
Authors

LUÍS M.T.R. LIMA

Abstract

Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide, and those non-diagnosed or misdiagnosed comprise a significant group compared to those diagnosed. Accumulated scientific evidence indicate that the current diagnostic markers (fasting glycemia, 2h glycemia after an oral glucose load and HbA1c) are indeed late diagnostic criteria when considering the incidence of diabetes-related complications and comorbidities, which are also at high risk in some groups among normoglycemic individuals. Additionally, the earlier identification of future risk of diabetes is desirable since it would allow better adherence to preventive actions such as lifestyle intervention, ultimately avoiding complications and minimizing the economic impact/burden on health care expenses. Insulin resistance and hyperhormonemia (insulin, amylin, glucagon) are non-disputable hallmarks of T2DM, which already takes place among these normoglycemic, otherwise health subjects, characterizing a state of subclinical diabetes. Insulin resistance and hyperinsulinemia can be computed from fasting plasma insulin as an independent variable in normoglycemia. An overview of the current diagnostic criteria, disease onset, complications, comorbidities and perspectives on lifestyle interventions are presented. A proposal for early detection of subclinical diabetes from routine evaluation of fasting plasma insulin, which is affordable and robust and thus applicable for the general population, is further suggested.

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Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 105 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 19%
Student > Bachelor 18 17%
Other 10 10%
Student > Doctoral Student 9 9%
Researcher 8 8%
Other 17 16%
Unknown 23 22%
Readers by discipline Count As %
Medicine and Dentistry 34 32%
Nursing and Health Professions 14 13%
Biochemistry, Genetics and Molecular Biology 11 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Agricultural and Biological Sciences 2 2%
Other 10 10%
Unknown 30 29%