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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

Overview of attention for article published in Nature, December 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Citations

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964 Dimensions

Readers on

mendeley
937 Mendeley
citeulike
6 CiteULike
Title
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Published in
Nature, December 2013
DOI 10.1038/nature12876
Pubmed ID
Authors

Frédéric Ariey, Benoit Witkowski, Chanaki Amaratunga, Johann Beghain, Anne-Claire Langlois, Nimol Khim, Saorin Kim, Valentine Duru, Christiane Bouchier, Laurence Ma, Pharath Lim, Rithea Leang, Socheat Duong, Sokunthea Sreng, Seila Suon, Char Meng Chuor, Denis Mey Bout, Sandie Ménard, William O. Rogers, Blaise Genton, Thierry Fandeur, Olivo Miotto, Pascal Ringwald, Jacques Le Bras, Antoine Berry, Jean-Christophe Barale, Rick M. Fairhurst, Françoise Benoit-Vical, Odile Mercereau-Puijalon, Didier Ménard

Abstract

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 937 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 8 <1%
United States 7 <1%
France 5 <1%
Brazil 3 <1%
Switzerland 2 <1%
Kenya 2 <1%
Ghana 2 <1%
Portugal 1 <1%
Norway 1 <1%
Other 17 2%
Unknown 889 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 224 24%
Researcher 165 18%
Student > Master 156 17%
Student > Bachelor 112 12%
Student > Doctoral Student 55 6%
Other 143 15%
Unknown 82 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 338 36%
Biochemistry, Genetics and Molecular Biology 165 18%
Medicine and Dentistry 121 13%
Chemistry 47 5%
Immunology and Microbiology 41 4%
Other 118 13%
Unknown 107 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 164. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2020.
All research outputs
#106,262
of 15,094,232 outputs
Outputs from Nature
#9,336
of 73,719 outputs
Outputs of similar age
#1,557
of 260,924 outputs
Outputs of similar age from Nature
#178
of 916 outputs
Altmetric has tracked 15,094,232 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 73,719 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 82.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 916 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.