Title |
Ranitidine reduced levodopa-induced dyskinesia in a rat model of Parkinson’s disease
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, December 2013
|
DOI | 10.2147/ndt.s54782 |
Pubmed ID | |
Authors |
Guiyun Cui, Xinxin Yang, Xiaoying Wang, Zunsheng Zhang, Xuanye Yue, Hongjuan Shi, Xia Shen |
Abstract |
Chronic administration of levodopa in Parkinson's disease leads to debilitating involuntary movements, termed levodopa-induced dyskinesia (LID). The pathogenesis of LID is poorly understood. Previous research has shown that histamine H2 receptors are highly expressed in the input (striatum) and output (globus pallidus, substantia nigra) regions of the basal ganglia, particularly in the GABAergic striatopallidal and striatonigral pathways. Therefore, a histamine H2 receptor antagonist could be used to reduce LID. In the present work, we investigated whether ranitidine has the potential to diminish LID in rats with dyskinesia and explored the underlying mechanisms involved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 24% |
Student > Master | 4 | 16% |
Student > Doctoral Student | 2 | 8% |
Student > Bachelor | 2 | 8% |
Professor | 1 | 4% |
Other | 3 | 12% |
Unknown | 7 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 20% |
Medicine and Dentistry | 4 | 16% |
Business, Management and Accounting | 3 | 12% |
Neuroscience | 2 | 8% |
Energy | 1 | 4% |
Other | 1 | 4% |
Unknown | 9 | 36% |