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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antibody-powered nucleic acid release using a DNA-based nanomachine
|
|---|---|
| Published in |
Nature Communications, May 2017
|
| DOI | 10.1038/ncomms15150 |
| Pubmed ID | |
| Authors |
Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle, Francesco Ricci |
| Abstract |
A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 30% |
| Italy | 2 | 5% |
| China | 2 | 5% |
| Spain | 2 | 5% |
| Canada | 2 | 5% |
| Belgium | 1 | 2% |
| Japan | 1 | 2% |
| United Kingdom | 1 | 2% |
| Congo, The Democratic Republic of the | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 17 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 73% |
| Scientists | 7 | 16% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 141 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 22% |
| Researcher | 17 | 12% |
| Student > Master | 16 | 11% |
| Student > Doctoral Student | 16 | 11% |
| Student > Bachelor | 15 | 10% |
| Other | 20 | 14% |
| Unknown | 27 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 36 | 25% |
| Biochemistry, Genetics and Molecular Biology | 31 | 22% |
| Agricultural and Biological Sciences | 19 | 13% |
| Engineering | 12 | 8% |
| Materials Science | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 25 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 193. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2023.
All research outputs
#204,110
of 25,347,980 outputs
Outputs from Nature Communications
#2,910
of 56,291 outputs
Outputs of similar age
#4,181
of 317,051 outputs
Outputs of similar age from Nature Communications
#66
of 1,020 outputs
Altmetric has tracked 25,347,980 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,291 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,020 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.