↓ Skip to main content

Antibody-powered nucleic acid release using a DNA-based nanomachine

Overview of attention for article published in Nature Communications, May 2017
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
20 news outlets
blogs
3 blogs
twitter
52 tweeters
patent
1 patent
facebook
17 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
109 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Antibody-powered nucleic acid release using a DNA-based nanomachine
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15150
Pubmed ID
Authors

Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle, Francesco Ricci

Abstract

A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

Twitter Demographics

The data shown below were collected from the profiles of 52 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Denmark 1 <1%
Unknown 107 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 23%
Researcher 16 15%
Student > Bachelor 14 13%
Student > Master 13 12%
Student > Doctoral Student 10 9%
Other 18 17%
Unknown 13 12%
Readers by discipline Count As %
Chemistry 27 25%
Biochemistry, Genetics and Molecular Biology 24 22%
Agricultural and Biological Sciences 18 17%
Engineering 12 11%
Materials Science 4 4%
Other 10 9%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 205. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2020.
All research outputs
#97,853
of 16,995,670 outputs
Outputs from Nature Communications
#1,398
of 33,162 outputs
Outputs of similar age
#3,214
of 272,433 outputs
Outputs of similar age from Nature Communications
#80
of 1,099 outputs
Altmetric has tracked 16,995,670 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,162 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,099 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.