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Antibody-powered nucleic acid release using a DNA-based nanomachine

Overview of attention for article published in Nature Communications, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
20 news outlets
blogs
3 blogs
twitter
44 X users
patent
1 patent
facebook
17 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
111 Dimensions

Readers on

mendeley
144 Mendeley
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Title
Antibody-powered nucleic acid release using a DNA-based nanomachine
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15150
Pubmed ID
Authors

Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle, Francesco Ricci

Abstract

A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

X Demographics

X Demographics

The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Denmark 1 <1%
Unknown 142 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 23%
Researcher 17 12%
Student > Master 16 11%
Student > Doctoral Student 16 11%
Student > Bachelor 15 10%
Other 20 14%
Unknown 27 19%
Readers by discipline Count As %
Chemistry 37 26%
Biochemistry, Genetics and Molecular Biology 31 22%
Agricultural and Biological Sciences 19 13%
Engineering 12 8%
Materials Science 5 3%
Other 15 10%
Unknown 25 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 193. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2023.
All research outputs
#210,770
of 25,877,363 outputs
Outputs from Nature Communications
#3,009
of 58,859 outputs
Outputs of similar age
#4,323
of 328,365 outputs
Outputs of similar age from Nature Communications
#65
of 1,022 outputs
Altmetric has tracked 25,877,363 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,859 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,365 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,022 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.