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Antibody-powered nucleic acid release using a DNA-based nanomachine

Overview of attention for article published in Nature Communications, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
20 news outlets
blogs
2 blogs
twitter
56 tweeters
facebook
17 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
69 Mendeley
Title
Antibody-powered nucleic acid release using a DNA-based nanomachine
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15150
Pubmed ID
Authors

Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle, Francesco Ricci

Abstract

A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

Twitter Demographics

The data shown below were collected from the profiles of 56 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Denmark 1 1%
Canada 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 26%
Researcher 13 19%
Student > Master 12 17%
Student > Bachelor 8 12%
Unspecified 4 6%
Other 14 20%
Readers by discipline Count As %
Chemistry 17 25%
Agricultural and Biological Sciences 16 23%
Biochemistry, Genetics and Molecular Biology 13 19%
Engineering 9 13%
Unspecified 6 9%
Other 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 200. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#54,528
of 12,172,600 outputs
Outputs from Nature Communications
#843
of 19,403 outputs
Outputs of similar age
#2,954
of 266,955 outputs
Outputs of similar age from Nature Communications
#59
of 994 outputs
Altmetric has tracked 12,172,600 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,403 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 994 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.