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Selective targeting of point-mutated KRAS through artificial microRNAs

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
14 tweeters

Citations

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19 Dimensions

Readers on

mendeley
40 Mendeley
Title
Selective targeting of point-mutated KRAS through artificial microRNAs
Published in
Proceedings of the National Academy of Sciences of the United States of America, May 2017
DOI 10.1073/pnas.1620562114
Pubmed ID
Authors

Mario Acunzo, Giulia Romano, Giovanni Nigita, Dario Veneziano, Luigi Fattore, Alessandro Laganà, Nicola Zanesi, Paolo Fadda, Matteo Fassan, Lara Rizzotto, Raleigh Kladney, Vincenzo Coppola, Carlo M. Croce

Abstract

Mutated protein-coding genes drive the molecular pathogenesis of many diseases, including cancer. Specifically, mutated KRAS is a documented driver for malignant transformation, occurring early during the pathogenesis of cancers such as lung and pancreatic adenocarcinomas. Therapeutically, the indiscriminate targeting of wild-type and point-mutated transcripts represents an important limitation. Here, we leveraged on the design of miRNA-like artificial molecules (amiRNAs) to specifically target point-mutated genes, such as KRAS, without affecting their wild-type counterparts. Compared with an siRNA-like approach, the requirement of perfect complementarity of the microRNA seed region to a given target sequence in the microRNA/target model has proven to be a more efficient strategy, accomplishing the selective targeting of point-mutated KRAS in vitro and in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 28%
Student > Ph. D. Student 8 20%
Student > Bachelor 6 15%
Other 4 10%
Professor 3 8%
Other 5 13%
Unknown 3 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 38%
Medicine and Dentistry 8 20%
Agricultural and Biological Sciences 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Computer Science 1 3%
Other 5 13%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2017.
All research outputs
#2,625,687
of 14,571,953 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#31,125
of 82,734 outputs
Outputs of similar age
#65,650
of 265,458 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#568
of 925 outputs
Altmetric has tracked 14,571,953 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,734 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,458 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 925 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.