Chapter title |
A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia
|
---|---|
Chapter number | 28 |
Book title |
ATM Kinase
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6955-5_28 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6953-1, 978-1-4939-6955-5
|
Authors |
Romal Stewart, Gautam Wali, Chris Perry, Martin F. Lavin, Francois Féron, Alan Mackay-Sim, Ratneswary Sutharsan, Stewart, Romal, Wali, Gautam, Perry, Chris, Lavin, Martin F., Féron, Francois, Mackay-Sim, Alan, Sutharsan, Ratneswary |
Editors |
Sergei V. Kozlov |
Abstract |
The molecular pathogenesis of ataxia-telangiectasia (A-T) is not yet fully understood, and a versatile cellular model is required for in vitro studies. The occurrence of continuous neurogenesis and easy access make the multipotent adult stem cells from the olfactory mucosa within the nasal cavity a potential cellular model. We describe an efficient method to establish neuron-like cells from olfactory mucosa biopsies derived from A-T patients for the purpose of studying the cellular and molecular aspects of this debilitating disease. |
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Unknown | 8 | 100% |
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Student > Ph. D. Student | 2 | 25% |
Student > Bachelor | 1 | 13% |
Student > Postgraduate | 1 | 13% |
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Neuroscience | 2 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 13% |
Chemistry | 1 | 13% |
Unknown | 4 | 50% |