Title |
Increased seroreactivity to HERV-K10 peptides in patients with HTLV myelopathy
|
---|---|
Published in |
Virology Journal, December 2013
|
DOI | 10.1186/1743-422x-10-360 |
Pubmed ID | |
Authors |
Raisa Perzova, Elliot Graziano, Swathi Sanghi, Caitlin Welch, Patricia Benz, Lynn Abbott, Danielle Lalone, Jordan Glaser, Thomas Loughran, William Sheremata, Bernard J Poiesz |
Abstract |
Previously, we had shown that persons infected with human T-cell lymphoma leukemia virus 1 or 2 (HTLV-1 or 2) had an increased prevalence of antibodies to a peptide in the Pol protein of the retrovirus HERV-K10, homologous to a peptide in HTLV gp21 envelope protein. The prevalence rate was higher in those with myelopathy vs. non-myelopathy. We have now extended our observations to a cohort restricted to North America in whom the diagnosis of HTLV myelopathy was rigorously confirmed to also test for reactivity to another HERV-K10 peptide homologous to the HTLV p24 Gag protein. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 50% |
Spain | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Master | 5 | 15% |
Student > Bachelor | 4 | 12% |
Researcher | 4 | 12% |
Student > Postgraduate | 3 | 9% |
Other | 2 | 6% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 21% |
Agricultural and Biological Sciences | 6 | 18% |
Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Immunology and Microbiology | 3 | 9% |
Neuroscience | 3 | 9% |
Other | 2 | 6% |
Unknown | 8 | 24% |