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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection
|
|---|---|
| Published in |
PLOS ONE, March 2012
|
| DOI | 10.1371/journal.pone.0034508 |
| Pubmed ID | |
| Authors |
Ying Kai Chan, I-Chueh Huang, Michael Farzan |
| Abstract |
Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| French Polynesia | 1 | 1% |
| Netherlands | 1 | 1% |
| Saint Kitts and Nevis | 1 | 1% |
| Indonesia | 1 | 1% |
| Brazil | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 77 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 29% |
| Researcher | 15 | 18% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 47% |
| Immunology and Microbiology | 12 | 14% |
| Medicine and Dentistry | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Social Sciences | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 7 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2022.
All research outputs
#2,605,961
of 25,382,035 outputs
Outputs from PLOS ONE
#31,968
of 220,434 outputs
Outputs of similar age
#15,470
of 172,002 outputs
Outputs of similar age from PLOS ONE
#509
of 3,736 outputs
Altmetric has tracked 25,382,035 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 220,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 3,736 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.