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Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Overview of attention for article published in Anais da Academia Brasileira de Ciências, March 2017
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Title
Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Published in
Anais da Academia Brasileira de Ciências, March 2017
DOI 10.1590/0001-3765201720160448
Pubmed ID
Authors

CAROLINE DANI, ANA CRISTINA ANDREAZZA, CARLOS ALBERTO GONÇALVES, FLÁVIO KAPIZINSKI, JOÃO A. P. HENRIQUES, MIRIAN SALVADOR

Abstract

Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.

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The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 16%
Student > Doctoral Student 5 13%
Researcher 4 11%
Student > Ph. D. Student 4 11%
Student > Master 2 5%
Other 4 11%
Unknown 13 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 13%
Agricultural and Biological Sciences 5 13%
Chemistry 2 5%
Medicine and Dentistry 2 5%
Neuroscience 2 5%
Other 8 21%
Unknown 14 37%