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The First Salamander Defensin Antimicrobial Peptide

Overview of attention for article published in PLOS ONE, December 2013
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Title
The First Salamander Defensin Antimicrobial Peptide
Published in
PLOS ONE, December 2013
DOI 10.1371/journal.pone.0083044
Pubmed ID
Authors

Ping Meng, Shilong Yang, Chuanbin Shen, Ke Jiang, Mingqiang Rong, Ren Lai

Abstract

Antimicrobial peptides have been widely identified from amphibian skins except salamanders. A novel antimicrobial peptide (CFBD) was isolated and characterized from skin secretions of the salamander, Cynops fudingensis. The cDNA encoding CFBD precursor was cloned from the skin cDNA library of C. fudingensis. The precursor was composed of three domains: signal peptide of 17 residues, mature peptide of 41 residues and intervening propeptide of 3 residues. There are six cysteines in the sequence of mature CFBD peptide, which possibly form three disulfide-bridges. CFBD showed antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Candida albicans and Escherichia coli. This peptide could be classified into family of β-defensin based on its sequence similarity with β-defensins from other vertebrates. Evolution analysis indicated that CFBD was close to fish β-defensin. As far as we know, CFBD is the first β-defensin antimicrobial peptide from salamanders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 23%
Student > Bachelor 12 15%
Student > Master 10 12%
Student > Doctoral Student 9 11%
Researcher 6 7%
Other 9 11%
Unknown 16 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 32%
Biochemistry, Genetics and Molecular Biology 20 25%
Pharmacology, Toxicology and Pharmaceutical Science 6 7%
Immunology and Microbiology 4 5%
Chemistry 2 2%
Other 6 7%
Unknown 17 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2014.
All research outputs
#7,438,092
of 22,738,543 outputs
Outputs from PLOS ONE
#88,438
of 194,081 outputs
Outputs of similar age
#91,855
of 305,083 outputs
Outputs of similar age from PLOS ONE
#2,212
of 5,441 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,081 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,083 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,441 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.