Title |
Heritability of Smoking Initiation and Nicotine Dependence
|
---|---|
Published in |
Behavior Genetics, July 2005
|
DOI | 10.1007/s10519-004-1327-8 |
Pubmed ID | |
Authors |
Jacqueline M. Vink, Gonneke Willemsen, Dorret I. Boomsma |
Abstract |
In contrast to other aspects of smoking behavior, little attention has been paid to the genetics of nicotine dependence. In this paper, three models (single liability dimension, independent liability dimension and combined model) have been applied to data on smoking initiation and nicotine dependence (n = 1572 Dutch twin pairs, mean age 30.5). A combined model best described the data. This model postulates a smoking initiation dimension and a nicotine dependence dimension, which are not independent. For both males and females, individual differences in smoking initiation were explained by genetic (44%), shared environmental (51%) and unique environmental (5%) influences. The nicotine dependence dimension was influenced only by genetic (75%) and unique environmental (25%) factors. The substantial impact of genetic factors on nicotine dependence emphasizes the need for further research to localize and identify specific genes and pathways involved in nicotine dependence. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 141 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 20% |
Researcher | 25 | 17% |
Student > Master | 20 | 14% |
Student > Doctoral Student | 10 | 7% |
Professor > Associate Professor | 9 | 6% |
Other | 32 | 22% |
Unknown | 21 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 24 | 16% |
Agricultural and Biological Sciences | 19 | 13% |
Medicine and Dentistry | 18 | 12% |
Neuroscience | 17 | 12% |
Biochemistry, Genetics and Molecular Biology | 11 | 7% |
Other | 29 | 20% |
Unknown | 29 | 20% |