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The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

Overview of attention for article published in Cell Communication and Signaling, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

blogs
1 blog
twitter
4 tweeters
f1000
1 research highlight platform

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
78 Mendeley
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Title
The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma
Published in
Cell Communication and Signaling, May 2017
DOI 10.1186/s12964-017-0175-0
Pubmed ID
Authors

Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren

Abstract

This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor types is mainly due to metastatic dissemination. Metastasis is facilitated by desmoplasia, a peculiar tumor microenvironment and the ability of the tumor cells to undergo epithelial-mesenchymal transition (EMT) and to adopt a motile and invasive phenotype. These processes are controlled entirely or in part by TGF-β and the small RHO GTPase RAC1 with both proteins acting as tumor promoters in late-stage cancers. Data from our and other studies point to signaling crosstalk between TGF-β and RAC1 and the related isoform, RAC1b, in pancreatic and mammary carcinoma cells. Based on the exciting observation that RAC1b functions as an endogenous inhibitor of RAC1, we propose a model on how the relative abundance or activity of RAC1 and RAC1b in the tumor cells may determine their responses to TGF-β and, ultimately, the metastatic capacity of the tumor.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 77 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 19%
Student > Ph. D. Student 12 15%
Student > Bachelor 12 15%
Researcher 6 8%
Student > Doctoral Student 5 6%
Other 12 15%
Unknown 16 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 32%
Agricultural and Biological Sciences 11 14%
Medicine and Dentistry 8 10%
Immunology and Microbiology 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 10 13%
Unknown 18 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2019.
All research outputs
#2,892,225
of 22,971,207 outputs
Outputs from Cell Communication and Signaling
#56
of 1,001 outputs
Outputs of similar age
#54,750
of 310,149 outputs
Outputs of similar age from Cell Communication and Signaling
#2
of 7 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,001 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,149 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.