@PWGTennant I think it overemphasises the study design label e.g. RCT is 'worshipped', and lacks much on the actual RoB associated with the individual study, see https://t.co/RZUEpT6r8k
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Sorry for piling on the extra reading! #PHJournal
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For complex conditions pragmatic RCTs are only way most patient can be represented in trials. Barnish & Turner explain value of pragmatic studies really well and give alarming example of only 1% of asthma patients meeting common trial inclusion criteri
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https://t.co/Kg7sGf2Fkz … #EBP #observationalstudies / randomised control trials - challenges in #medicine and therefore, possibly #SLT