https://t.co/D1SuPcqOyj "In conclusion, our results show that improved anti-cancer efficacy can be achieved by co-targeting the AR axis and fat oxidation via CPT1A, which may have clinical implications, especially in the mCRPC setting."
3,569 followers
3,569 followers
https://t.co/D1SuPcqOyj "Lastly, using a xenograft mouse model, we have observed decreased tumor growth with a systemic combination treatment of enzalutamide and ranolazine."
3,569 followers
https://t.co/D1SuPcqOyj "To better understand the clinical implications of these findings, we have evaluated fat oxidation inhibitors (etomoxir, ranolazine and perhexiline) in combination with enzalutamide in PCa cell models."
3,569 followers
https://t.co/D1SuPcqgIL "This results in increased androgen receptor (AR) action and increased sensitivity to the anti-androgen enzalutamide."