Title |
Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept
|
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Published in |
CNS Drugs, August 2012
|
DOI | 10.2165/11588400-000000000-00000 |
Pubmed ID | |
Authors |
Edward Tobinick |
Abstract |
Thrombolytic therapy reduces stroke size and disability by reperfusion and salvage of ischaemic penumbra. Emerging evidence suggests that retrieved penumbra may be the site of ongoing inflammatory pathology that includes extensive microglial activation. Microglial activation may be associated with excessive levels of tumour necrosis factor (TNF) and resultant neurotoxicity. Etanercept, a potent biologic TNF antagonist, reduces microglial activation in experimental models and has been therapeutically effective in models of brain and neuronal injury. Perispinal administration of etanercept, previously reported to be beneficial for the treatment of Alzheimer's disease, may facilitate delivery of etanercept into the brain. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Australia | 2 | 40% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 3% |
United States | 1 | <1% |
Unknown | 97 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 19% |
Student > Bachelor | 19 | 19% |
Student > Master | 13 | 13% |
Researcher | 8 | 8% |
Student > Doctoral Student | 8 | 8% |
Other | 13 | 13% |
Unknown | 21 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 25% |
Psychology | 13 | 13% |
Nursing and Health Professions | 9 | 9% |
Agricultural and Biological Sciences | 9 | 9% |
Neuroscience | 5 | 5% |
Other | 13 | 13% |
Unknown | 27 | 27% |