Title |
Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
|
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Published in |
Clinical Ophthalmology, January 2014
|
DOI | 10.2147/opth.s56327 |
Pubmed ID | |
Authors |
Shinji Makino, Hironobu Tampo, Yusuke Arai, Hiroto Obata |
Abstract |
To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. Patients ranged in age from 4 to 39 years. The angle used for near-infrared reflectance imaging was 55°. We counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and the total number of Lisch nodules on the iris by slit-lamp examination. No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P=0.7414). Choroidal abnormalities tended to increase with age (ρ=0.6150), but this difference was not statistically significant (P=0.0650). A positive correlation was found between the number of choroidal abnormalities and Lisch nodules (ρ=0.783, P=0.0267). In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules. |
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