Title |
Failure of dihydroartemisinin-piperaquine treatment of uncomplicated Plasmodium falciparum malaria in a traveller coming from Ethiopia
|
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Published in |
Malaria Journal, November 2016
|
DOI | 10.1186/s12936-016-1572-3 |
Pubmed ID | |
Authors |
Federico Gobbi, Dora Buonfrate, Michela Menegon, Gianluigi Lunardi, Andrea Angheben, Carlo Severini, Stefania Gori, Zeno Bisoffi |
Abstract |
Artemisinin combination therapy (ACT) is used worldwide as the first-line treatment against uncomplicated Plasmodium falciparum malaria. Despite the success of ACT in reducing the global burden of malaria, the emerging of resistance to artemisinin threatens its use. This report describes the first case of failure of dihydroartemisinin-piperaquine (DHA-PPQ) for the treatment of P. falciparum malaria diagnosed in Europe. It occurred in an Italian tourist returned from Ethiopia. She completely recovered after the DHA-PPQ treatment but 32 days after the end of therapy she had a recrudescence. The retrospective analysis indicated a correct DHA-PPQ absorption and genotyping demonstrated that the same P. falciparum strain was responsible for the both episodes. In consideration of the growing number of cases of resistance to ACT, it is important to consider a possible recrudescence, that can manifest also several weeks after treatment. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Vietnam | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 18% |
Student > Bachelor | 5 | 13% |
Researcher | 5 | 13% |
Student > Doctoral Student | 3 | 8% |
Other | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 35% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Agricultural and Biological Sciences | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Unspecified | 1 | 3% |
Other | 3 | 8% |
Unknown | 17 | 43% |