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Breaking the diffraction-limited resolution barrier in fiber-optical two-photon fluorescence endoscopy by an azimuthally-polarized beam

Overview of attention for article published in Scientific Reports, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
2 news outlets
twitter
5 tweeters

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
87 Mendeley
Title
Breaking the diffraction-limited resolution barrier in fiber-optical two-photon fluorescence endoscopy by an azimuthally-polarized beam
Published in
Scientific Reports, January 2014
DOI 10.1038/srep03627
Pubmed ID
Authors

Min Gu, Hong Kang, Xiangping Li

Abstract

Although fiber-optical two-photon endoscopy has been recognized as a potential high-resolution diagnostic and therapeutic procedure in vivo, its resolution is limited by the optical diffraction nature to a few micrometers due to the low numerical aperture of an endoscopic objective. On the other hand, stimulated emission depletion (STED) achieved by a circularly-polarized vortex beam has been used to break the diffraction-limited resolution barrier in a bulky microscope. It has been a challenge to apply the STED principle to a fiber-optical two-photon endoscope as a circular polarization state cannot be maintained due to the birefringence of a fiber. Here, we demonstrate the first fiber-optical STED two-photon endoscope using an azimuthally-polarized beam directly generated from a double-clad fiber. As such, the diffraction-limited resolution barrier of fiber-optical two-photon endoscopy can be broken by a factor of three. Our new accomplishment has paved a robust way for high-resolution in vivo biomedical studies.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
France 2 2%
Brazil 1 1%
Korea, Republic of 1 1%
Spain 1 1%
Germany 1 1%
Unknown 79 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 29%
Student > Ph. D. Student 24 28%
Student > Master 9 10%
Professor > Associate Professor 6 7%
Student > Bachelor 5 6%
Other 13 15%
Unknown 5 6%
Readers by discipline Count As %
Physics and Astronomy 31 36%
Engineering 26 30%
Agricultural and Biological Sciences 7 8%
Materials Science 4 5%
Medicine and Dentistry 2 2%
Other 7 8%
Unknown 10 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2014.
All research outputs
#926,408
of 14,223,521 outputs
Outputs from Scientific Reports
#8,869
of 73,086 outputs
Outputs of similar age
#17,553
of 258,462 outputs
Outputs of similar age from Scientific Reports
#277
of 2,101 outputs
Altmetric has tracked 14,223,521 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 73,086 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,462 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2,101 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.