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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder
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|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, May 2017
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| DOI | 10.1007/s00406-017-0806-x |
| Pubmed ID | |
| Authors |
Annegret Krause-Utz, Dorina Winter, Friederike Schriner, Chui-De Chiu, Stefanie Lis, Philip Spinhoven, Martin Bohus, Christian Schmahl, Bernet M. Elzinga |
| Abstract |
Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the context of a working memory task in BPD. We aimed to investigate whole-brain activity and amygdala functional connectivity (FC) during an Emotional Working Memory Task (EWMT) after dissociation induction in un-medicated BPD patients compared to healthy controls (HC). Using script-driven imagery, dissociation was induced in 17 patients ('BPD_D'), while 12 patients ('BPD_N') and 18 HC were exposed to neutral scripts during fMRI. Afterwards, participants performed the EWMT with neutral vs. negative IAPS pictures vs. no distractors. Main outcome measures were behavioral performance (reaction times, errors) and whole-brain activity during the EWMT. Psychophysiological interaction analysis was used to examine amygdala connectivity during emotional distraction. BPD patients after dissociation induction showed overall WM impairments, a deactivation in bilateral amygdala, and lower activity in left cuneus, lingual gyrus, and posterior cingulate than BPD_N, along with stronger left inferior frontal gyrus activity than HC. Furthermore, reduced amygdala FC with fusiform gyrus and stronger amygdala FC with right middle/superior temporal gyrus and left inferior parietal lobule was observed in BPD_D. Findings suggest that dissociation affects reactivity to emotionally salient material and WM. Altered activity in areas associated with emotion processing, memory, and self-referential processes may contribute to dissociative states in BPD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 15% |
| Student > Master | 16 | 11% |
| Researcher | 15 | 10% |
| Student > Ph. D. Student | 15 | 10% |
| Student > Doctoral Student | 11 | 7% |
| Other | 23 | 15% |
| Unknown | 49 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 52 | 34% |
| Neuroscience | 16 | 11% |
| Medicine and Dentistry | 14 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Nursing and Health Professions | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 55 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2017.
All research outputs
#18,550,468
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#939
of 1,243 outputs
Outputs of similar age
#225,702
of 314,232 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#18
of 26 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,232 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.