Title |
Trafficking regulation of proteins in Alzheimer’s disease
|
---|---|
Published in |
Molecular Neurodegeneration, January 2014
|
DOI | 10.1186/1750-1326-9-6 |
Pubmed ID | |
Authors |
Shangtong Jiang, Yanfang Li, Xian Zhang, Guojun Bu, Huaxi Xu, Yun-wu Zhang |
Abstract |
The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD. |
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Brazil | 1 | 20% |
Spain | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
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Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
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Czechia | 1 | <1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 31 | 16% |
Researcher | 26 | 13% |
Student > Bachelor | 20 | 10% |
Student > Doctoral Student | 12 | 6% |
Other | 28 | 14% |
Unknown | 25 | 13% |
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Chemistry | 5 | 3% |
Other | 16 | 8% |
Unknown | 32 | 16% |