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HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3

Overview of attention for article published in Retrovirology, January 2014
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38 Mendeley
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Title
HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3
Published in
Retrovirology, January 2014
DOI 10.1186/1742-4690-11-4
Pubmed ID
Authors

Sean L Evans, Arne Schön, Qimeng Gao, Xue Han, Xiaohong Zhou, Ernesto Freire, Xiao-Fang Yu

Abstract

HIV-1 Vif promotes the degradation of host anti-retroviral factor family, APOBEC3 proteins via the recruitment of a multi-subunit E3 ubiquitin ligase complex. The complex is composed of a scaffold protein, Cullin 5 (Cul5), RING-box protein (Rbx), a SOCS box binding protein complex, Elongins B/C (Elo B/C), as well as newly identified host co-factor, core binding factor beta (CBF-β). Cul5 has previously been shown to bind amino acids within an HCCH domain as well as a PPLP motif at the C-terminus of Vif; however, it is unclear whether Cul5 binding requires additional regions of the Vif polypeptide.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Portugal 1 3%
Sweden 1 3%
Unknown 35 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 29%
Researcher 11 29%
Professor 3 8%
Student > Doctoral Student 3 8%
Student > Master 2 5%
Other 3 8%
Unknown 5 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 37%
Agricultural and Biological Sciences 10 26%
Immunology and Microbiology 4 11%
Chemistry 2 5%
Medicine and Dentistry 2 5%
Other 1 3%
Unknown 5 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2014.
All research outputs
#14,431,072
of 23,577,654 outputs
Outputs from Retrovirology
#678
of 1,118 outputs
Outputs of similar age
#174,392
of 310,263 outputs
Outputs of similar age from Retrovirology
#22
of 42 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,118 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,263 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.