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Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2017
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Title
Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables
Published in
Anais da Academia Brasileira de Ciências, May 2017
DOI 10.1590/0001-3765201720160509
Pubmed ID
Authors

Bernardita Monsalve, Anibal Concha-Meyer, Iván Palomo, Eduardo Fuentes

Abstract

The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words: endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases. In this context, high intakes of fruit and vegetables are associated with the decrease of cardiovascular diseases. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In this article natural bioactive compound mechanisms of endothelium protection are thoroughly reviewed.

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Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 15%
Student > Master 15 14%
Researcher 9 8%
Student > Ph. D. Student 9 8%
Other 7 7%
Other 23 21%
Unknown 28 26%
Readers by discipline Count As %
Medicine and Dentistry 15 14%
Agricultural and Biological Sciences 10 9%
Nursing and Health Professions 8 7%
Biochemistry, Genetics and Molecular Biology 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Other 19 18%
Unknown 40 37%