Title |
Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model
|
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Published in |
Virology Journal, January 2014
|
DOI | 10.1186/1743-422x-11-10 |
Pubmed ID | |
Authors |
Zixue Shi, Jianchao Wei, Xufang Deng, Shuqing Li, Yafeng Qiu, Donghua Shao, Beibei Li, Keyu Zhang, Feiqun Xue, Xiaodu Wang, Zhiyong Ma |
Abstract |
Japanese encephalitis virus (JEV) has a significant impact on public health. An estimated three billion people in 'at-risk' regions remain unvaccinated and the number of unvaccinated individuals in certain Asian countries is increasing. Consequently, there is an urgent need for the development of novel therapeutic agents against Japanese encephalitis. Nitazoxanide (NTZ) is a thiazolide anti-infective licensed for the treatment of parasitic gastroenteritis. Recently, NTZ has been demonstrated to have antiviral properties. In this study, the anti-JEV activity of NTZ was evaluated in cultured cells and in a mouse model. |
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