↓ Skip to main content

Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesions

Overview of attention for article published in Scientific Reports, January 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
10 news outlets
twitter
6 tweeters
facebook
7 Facebook pages

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
74 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesions
Published in
Scientific Reports, January 2014
DOI 10.1038/srep03839
Pubmed ID
Authors

Amol P. Yadav, Romulo Fuentes, Hao Zhang, Thais Vinholo, Chi-Han Wang, Marco Aurelio M. Freire, Miguel A. L. Nicolelis

Abstract

Although L-dopa continues to be the gold standard for treating motor symptoms of Parkinson's disease (PD), it presents long-term complications. Deep brain stimulation is effective, but only a small percentage of idiopathic PD patients are eligible. Based on results in animal models and a handful of patients, dorsal column stimulation (DCS) has been proposed as a potential therapy for PD. To date, the long-term effects of DCS in animal models have not been quantified. Here, we report that DCS applied twice a week in rats treated with bilateral 6-OHDA striatal infusions led to a significant improvement in symptoms. DCS-treated rats exhibited a higher density of dopaminergic innervation in the striatum and higher neuronal cell count in the substantia nigra pars compacta compared to a control group. These results suggest that DCS has a chronic therapeutical and neuroprotective effect, increasing its potential as a new clinical option for treating PD patients.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Canada 1 1%
Brazil 1 1%
Unknown 68 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 23%
Student > Ph. D. Student 12 16%
Student > Bachelor 11 15%
Student > Master 10 14%
Student > Doctoral Student 6 8%
Other 12 16%
Unknown 6 8%
Readers by discipline Count As %
Medicine and Dentistry 16 22%
Neuroscience 16 22%
Agricultural and Biological Sciences 12 16%
Engineering 10 14%
Psychology 3 4%
Other 5 7%
Unknown 12 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#305,540
of 17,043,172 outputs
Outputs from Scientific Reports
#3,606
of 91,112 outputs
Outputs of similar age
#4,234
of 262,016 outputs
Outputs of similar age from Scientific Reports
#2
of 90 outputs
Altmetric has tracked 17,043,172 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 91,112 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.