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Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesions

Overview of attention for article published in Scientific Reports, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
10 news outlets
twitter
7 tweeters
facebook
7 Facebook pages
video
1 video uploader

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
67 Mendeley
Title
Chronic Spinal Cord Electrical Stimulation Protects Against 6-hydroxydopamine Lesions
Published in
Scientific Reports, January 2014
DOI 10.1038/srep03839
Pubmed ID
Authors

Amol P. Yadav, Romulo Fuentes, Hao Zhang, Thais Vinholo, Chi-Han Wang, Marco Aurelio M. Freire, Miguel A. L. Nicolelis

Abstract

Although L-dopa continues to be the gold standard for treating motor symptoms of Parkinson's disease (PD), it presents long-term complications. Deep brain stimulation is effective, but only a small percentage of idiopathic PD patients are eligible. Based on results in animal models and a handful of patients, dorsal column stimulation (DCS) has been proposed as a potential therapy for PD. To date, the long-term effects of DCS in animal models have not been quantified. Here, we report that DCS applied twice a week in rats treated with bilateral 6-OHDA striatal infusions led to a significant improvement in symptoms. DCS-treated rats exhibited a higher density of dopaminergic innervation in the striatum and higher neuronal cell count in the substantia nigra pars compacta compared to a control group. These results suggest that DCS has a chronic therapeutical and neuroprotective effect, increasing its potential as a new clinical option for treating PD patients.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 6%
Canada 1 1%
Brazil 1 1%
Unknown 61 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 25%
Student > Ph. D. Student 13 19%
Student > Master 10 15%
Student > Bachelor 9 13%
Student > Doctoral Student 5 7%
Other 10 15%
Unknown 3 4%
Readers by discipline Count As %
Medicine and Dentistry 15 22%
Neuroscience 15 22%
Agricultural and Biological Sciences 12 18%
Engineering 9 13%
Psychology 3 4%
Other 4 6%
Unknown 9 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#251,323
of 15,168,086 outputs
Outputs from Scientific Reports
#3,021
of 78,148 outputs
Outputs of similar age
#3,951
of 252,532 outputs
Outputs of similar age from Scientific Reports
#1
of 3 outputs
Altmetric has tracked 15,168,086 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,148 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them