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Molecular chaperones and selection against mutations

Overview of attention for article published in Biology Direct, February 2008
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Title
Molecular chaperones and selection against mutations
Published in
Biology Direct, February 2008
DOI 10.1186/1745-6150-3-5
Pubmed ID
Authors

Katarzyna Tomala, Ryszard Korona

Abstract

Molecular chaperones help to restore the native states of proteins after their destabilization by external stress. It has been proposed that another function of chaperones is to maintain the activity of proteins destabilized by mutation, weakening the selection against suboptimal protein variants. This would allow for the accumulation of genetic variation which could then be exposed during environmental perturbation and facilitate rapid adaptation.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 1%
Chile 1 1%
United Kingdom 1 1%
Estonia 1 1%
United States 1 1%
Unknown 70 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 33%
Student > Ph. D. Student 19 25%
Student > Bachelor 7 9%
Student > Postgraduate 6 8%
Professor 6 8%
Other 10 13%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 65%
Biochemistry, Genetics and Molecular Biology 16 21%
Medicine and Dentistry 2 3%
Physics and Astronomy 1 1%
Immunology and Microbiology 1 1%
Other 2 3%
Unknown 4 5%