Title |
Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution
|
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Published in |
Biology Direct, April 2010
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DOI | 10.1186/1745-6150-5-31 |
Pubmed ID | |
Authors |
Marina V Omelchenko, Michael Y Galperin, Yuri I Wolf, Eugene V Koonin |
Abstract |
Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC) numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted) to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (non)homologous relationships between proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 4 | 2% |
United States | 3 | 2% |
Canada | 2 | 1% |
United Kingdom | 2 | 1% |
Portugal | 1 | <1% |
Japan | 1 | <1% |
France | 1 | <1% |
Unknown | 161 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 49 | 28% |
Student > Ph. D. Student | 35 | 20% |
Student > Master | 17 | 10% |
Student > Bachelor | 15 | 9% |
Professor > Associate Professor | 12 | 7% |
Other | 28 | 16% |
Unknown | 19 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 82 | 47% |
Biochemistry, Genetics and Molecular Biology | 51 | 29% |
Computer Science | 7 | 4% |
Chemistry | 2 | 1% |
Nursing and Health Professions | 1 | <1% |
Other | 6 | 3% |
Unknown | 26 | 15% |