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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution
|
|---|---|
| Published in |
Biology Direct, April 2010
|
| DOI | 10.1186/1745-6150-5-31 |
| Pubmed ID | |
| Authors |
Marina V Omelchenko, Michael Y Galperin, Yuri I Wolf, Eugene V Koonin |
| Abstract |
Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC) numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted) to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (non)homologous relationships between proteins. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 4 | 2% |
| United States | 3 | 2% |
| Canada | 2 | 1% |
| United Kingdom | 2 | 1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| France | 1 | <1% |
| Unknown | 162 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 49 | 28% |
| Student > Ph. D. Student | 35 | 20% |
| Student > Master | 17 | 10% |
| Student > Bachelor | 15 | 9% |
| Professor > Associate Professor | 12 | 7% |
| Other | 29 | 16% |
| Unknown | 19 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 47% |
| Biochemistry, Genetics and Molecular Biology | 51 | 29% |
| Computer Science | 7 | 4% |
| Chemistry | 2 | 1% |
| Environmental Science | 1 | <1% |
| Other | 7 | 4% |
| Unknown | 26 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2024.
All research outputs
#7,222,162
of 23,556,846 outputs
Outputs from Biology Direct
#247
of 493 outputs
Outputs of similar age
#32,948
of 96,441 outputs
Outputs of similar age from Biology Direct
#3
of 6 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 493 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,441 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.