Title |
Assessment of liver stiffness in patients with HCV and mixed cryoglobulinemia undergoing rituximab treatment
|
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Published in |
Journal of Translational Medicine, January 2014
|
DOI | 10.1186/1479-5876-12-21 |
Pubmed ID | |
Authors |
Cristina Stasi, Elisa Triboli, Umberto Arena, Teresa Urraro, Antonio Petrarca, Laura Gragnani, Giacomo Laffi, Anna Linda Zignego |
Abstract |
Mixed cryoglobulinemia (MC) is a HCV-related lymphoproliferative disorder generally associated with advanced liver disease. Liver stiffness has been significantly correlated with histopathological stage of fibrosis. Moreover, it was influenced by necroinflammatory activity. Rituximab (RTX) is a chimeric anti-CD20 monoclonal antibody inducing transient B lymphocytes depletion that was shown to be useful and safe in the majority of HCV MC patients, leading also to improvement of cirrhotic syndrome. Aim of this study was to evaluate the modifications of liver stiffness following RTX treatment in HCV-related MC patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 3% |
Italy | 1 | 3% |
Canada | 1 | 3% |
Unknown | 27 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 20% |
Student > Bachelor | 5 | 17% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Other | 2 | 7% |
Other | 4 | 13% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 50% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 33% |