Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

Biology of Mood & Anxiety Disorders, January 2014

24447313

Orna Issler, Roderick N Carter, Evan D Paul, Paul AT Kelly, Henry J Olverman, Adi Neufeld-Cohen, Yael Kuperman, Christopher A Lowry, Jonathan R Seckl, Alon Chen, Pauline M Jamieson

Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulate serotonergic neuronal activity and have been demonstrated to mediate behavioural consequences of stress. Here, we describe behavioural and serotonergic responses consistent with maladaptive recovery from stressful challenge in CRFR2-null mice.