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Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period1

Overview of attention for article published in Acta Cirúrgica Brasileira, January 2016
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Title
Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period1
Published in
Acta Cirúrgica Brasileira, January 2016
DOI 10.1590/s0102-86502016001300006
Pubmed ID
Authors

Sofia Miranda de Figueiredo Ribeiro, Amanda Maria Tomazini Munhoz Moya, Camila Bitu Moreno Braga, Fernanda Aparecida Domenici, Marley Ribeiro Feitosa, Omar Feres, José Joaquim Ribeiro da Rocha, Selma Freire de Carvalho da Cunha

Abstract

This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin[70.1 ng/mL (CI95% 55.8-84.5) vs.53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations [120 µg/dL(CI95% 114-126) vs. 106 µg/dL(CI95% 98-114), p<0.01] and the Cu/Zn ratio [1.59 (CI95% 1.48-1.71)vs. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.

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Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 14%
Researcher 5 14%
Student > Ph. D. Student 5 14%
Student > Master 3 8%
Professor 2 5%
Other 5 14%
Unknown 12 32%
Readers by discipline Count As %
Medicine and Dentistry 12 32%
Biochemistry, Genetics and Molecular Biology 2 5%
Nursing and Health Professions 2 5%
Chemistry 2 5%
Sports and Recreations 1 3%
Other 3 8%
Unknown 15 41%