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The effect of immunoregulation of Streptococcus lactis L16 strain upon Staphylococcus aureus infection

Overview of attention for article published in BMC Microbiology, June 2017
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Title
The effect of immunoregulation of Streptococcus lactis L16 strain upon Staphylococcus aureus infection
Published in
BMC Microbiology, June 2017
DOI 10.1186/s12866-017-1038-y
Pubmed ID
Authors

Maopeng Wang, Shengjie Gong, Shouwen Du, Yilong Zhu, Fengjun Rong, Rongrong Pan, Yang Di, Chang Li, Dayong Ren, Ningyi Jin

Abstract

Staphylococcus aureus is an important pathogen that causes various infections in medical facilities. However, resistance to multiple drugs has made this infection difficult to manage. Thus, new therapeutic strategies are urgently needed to solve this worldwide public health problem. The Streptococcus lactis L16 strain was isolated from the fermented hot chili sauce. To explore whether it can be used as a protective agent against S. aureus infection, we designed a mouse model of S. aureus infection to evaluate the therapeutic potency of S. lactis. Mice were grouped into pre-(P) and post-(T) S. aureus infection groups following oral administration of S. lactis L16. The protection and treatment effects were assessed by examining body weight, internal organ weight, serum cytokines and intestinal secretory IgA alternations. Oral administration of the S. lactis L16 strain reduced the loss of body weight in mice post-infection and alleviated infection-induced hepatomegaly. In particular, the PL16 group (protection with L16) showed more effective resistance to S. aureus than the TL16 group (treatment with L16). The level of serum cytokine interferon gamma following oral administration of the L16 strain was remarkably increased during infection, as were interleukin-4 levels during convalescence. The probiotic L16 strain induced more sIgA production than S. aureus. Our data suggest that S. lactis L16 is an effective strain with anti-Staphylococcus activity. By regulating the Th1/Th2 response, S. lactis can effectively reduce lesions from infection, indicating its therapeutic potential in overcoming antibiotic resistance in this mouse infection model that mimics infections observed in humans.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 25%
Researcher 2 17%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Student > Ph. D. Student 1 8%
Other 2 17%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Agricultural and Biological Sciences 2 17%
Biochemistry, Genetics and Molecular Biology 1 8%
Immunology and Microbiology 1 8%
Veterinary Science and Veterinary Medicine 1 8%
Other 0 0%
Unknown 4 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2017.
All research outputs
#9,995,118
of 12,488,061 outputs
Outputs from BMC Microbiology
#1,262
of 1,839 outputs
Outputs of similar age
#192,622
of 266,184 outputs
Outputs of similar age from BMC Microbiology
#1
of 1 outputs
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