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Reduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization

Overview of attention for article published in Cilia, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
37 Mendeley
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Title
Reduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization
Published in
Cilia, January 2014
DOI 10.1186/2046-2530-3-2
Pubmed ID
Authors

Tyler Picariello, Megan Smith Valentine, Junji Yano, Judith Van Houten

Abstract

Meckelin (MKS3), a conserved protein linked to Meckel Syndrome, assists in the migration of centrioles to the cell surface for ciliogenesis. We explored for additional functions of MKS3p using RNA interference (RNAi) and expression of FLAG epitope tagged protein in the ciliated protozoan Paramecium tetraurelia. This cell has a highly organized cell surface with thousands of cilia and basal bodies that are grouped into one or two basal body units delineated by ridges. The highly systematized nature of the P. tetraurelia cell surface provides a research model of MKS and other ciliopathies where changes in ciliary structure, subcellular organization and overall arrangement of the cell surface can be easily observed. We used cells reduced in IFT88 for comparison, as the involvement of this gene's product with cilia maintenance and growth is well understood.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 32%
Student > Ph. D. Student 9 24%
Student > Bachelor 6 16%
Student > Master 3 8%
Student > Doctoral Student 2 5%
Other 2 5%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 46%
Biochemistry, Genetics and Molecular Biology 9 24%
Nursing and Health Professions 2 5%
Neuroscience 2 5%
Medicine and Dentistry 2 5%
Other 2 5%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2014.
All research outputs
#2,973,966
of 17,353,889 outputs
Outputs from Cilia
#10
of 89 outputs
Outputs of similar age
#42,871
of 263,552 outputs
Outputs of similar age from Cilia
#2
of 4 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 89 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,552 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.