Chapter title |
Dynamic Regulation of NK Cell Responsiveness.
|
---|---|
Chapter number | 485 |
Book title |
Natural Killer Cells
|
Published in |
Current topics in microbiology and immunology, December 2015
|
DOI | 10.1007/82_2015_485 |
Pubmed ID | |
Book ISBNs |
978-3-31-923915-6, 978-3-31-923916-3
|
Authors |
Kadri, Nadir, Wagner, Arnika Kathleen, Ganesan, Sridharan, Kärre, Klas, Wickström, Stina, Johansson, Maria H, Höglund, Petter, Nadir Kadri, Arnika Kathleen Wagner, Sridharan Ganesan, Klas Kärre, Stina Wickström, Maria H. Johansson, Petter Höglund, Johansson, Maria H. |
Abstract |
Natural killer (NK) cells deliver cytotoxic granules and immunomodulatory cytokines in response to transformed and virally infected cells. NK cell functions are under the control of a large number of germline-encoded receptors that recognize various ligands on target cells, but NK cells also respond to cytokines in the surrounding environment. The interaction between NK cell receptors and their ligands delivers either inhibitory or activating signals. The cytokine milieu further shapes NK cell responses, either directly or by influencing the way inhibitory or activating signals are perceived by NK cells. In this review, we discuss how NK cell function is controlled by inhibitory receptors and MHC-I molecules, how activating receptors contribute to NK cell education, and finally, how cytokines secreted by the surrounding cells affect NK cell responsiveness. Inputs at these three levels involve different cell types and are seamlessly integrated to form a functional NK cell population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 19% |
Student > Ph. D. Student | 4 | 19% |
Student > Bachelor | 3 | 14% |
Student > Postgraduate | 2 | 10% |
Lecturer | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 7 | 33% |
Medicine and Dentistry | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Agricultural and Biological Sciences | 2 | 10% |
Unknown | 4 | 19% |