Title |
Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation
|
---|---|
Published in |
Journal of Neuroinflammation, February 2014
|
DOI | 10.1186/1742-2094-11-23 |
Pubmed ID | |
Authors |
Daphne YS Vogel, Priscilla DAM Heijnen, Marjolein Breur, Helga E de Vries, Anton TJ Tool, Sandra Amor, Christine D Dijkstra |
Abstract |
In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration within the central nervous system may be of critical importance in the final outcome of neurodegeneration in neuroinflammatory diseases e.g. multiple sclerosis (MS). To provide insight into this process, we examined the migratory capacity of human monocyte-derived M1 and M2 polarised macrophages towards chemoattractants, relevant for neuroinflammatory diseases like MS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Germany | 2 | <1% |
Spain | 1 | <1% |
Unknown | 243 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 75 | 30% |
Student > Master | 34 | 14% |
Researcher | 30 | 12% |
Student > Bachelor | 24 | 10% |
Student > Doctoral Student | 20 | 8% |
Other | 23 | 9% |
Unknown | 43 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 19% |
Biochemistry, Genetics and Molecular Biology | 40 | 16% |
Medicine and Dentistry | 31 | 12% |
Immunology and Microbiology | 30 | 12% |
Engineering | 14 | 6% |
Other | 33 | 13% |
Unknown | 53 | 21% |