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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
|
|---|---|
| Published in |
Nature Genetics, February 2014
|
| DOI | 10.1038/ng.2889 |
| Pubmed ID | |
| Authors |
Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya |
| Abstract |
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein-binding protein Lis1 is critically required for hematopoietic stem cell function and leukemogenesis. Conditional deletion of Lis1 (also known as Pafah1b1) in the hematopoietic system led to a severe bloodless phenotype, depletion of the stem cell pool and embryonic lethality. Further, real-time imaging revealed that loss of Lis1 caused defects in spindle positioning and inheritance of cell fate determinants, triggering accelerated differentiation. Finally, deletion of Lis1 blocked the propagation of myeloid leukemia and led to a marked improvement in survival, suggesting that Lis1 is also required for oncogenic growth. These data identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 63% |
| France | 1 | 13% |
| United Kingdom | 1 | 13% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Austria | 1 | <1% |
| Unknown | 152 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 24% |
| Researcher | 37 | 24% |
| Student > Master | 17 | 11% |
| Student > Bachelor | 8 | 5% |
| Other | 8 | 5% |
| Other | 25 | 16% |
| Unknown | 23 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 39% |
| Biochemistry, Genetics and Molecular Biology | 37 | 24% |
| Medicine and Dentistry | 16 | 10% |
| Engineering | 5 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Other | 11 | 7% |
| Unknown | 23 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2015.
All research outputs
#591,890
of 22,743,667 outputs
Outputs from Nature Genetics
#1,188
of 7,184 outputs
Outputs of similar age
#6,859
of 307,308 outputs
Outputs of similar age from Nature Genetics
#20
of 62 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.