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Green synthesis of enzyme/metal-organic framework composites with high stability in protein denaturing solvents

Overview of attention for article published in Bioresources and Bioprocessing, May 2017
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1 tweeter

Citations

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Title
Green synthesis of enzyme/metal-organic framework composites with high stability in protein denaturing solvents
Published in
Bioresources and Bioprocessing, May 2017
DOI 10.1186/s40643-017-0154-8
Pubmed ID
Authors

Xiaoling Wu, Cheng Yang, Jun Ge

Abstract

Enzyme/metal-organic framework composites with high stability in protein denaturing solvents were reported in this study. Encapsulation of enzyme in metal-organic frameworks (MOFs) via co-precipitation process was realized, and the generality of the synthesis was validated by using cytochrome c, horseradish peroxidase, and Candida antarctica lipase B as model enzymes. The stability of encapsulated enzyme was greatly increased after immobilization on MOFs. Remarkably, when exposed to protein denaturing solvents including dimethyl sulfoxide, dimethyl formamide, methanol, and ethanol, the enzyme/MOF composites still preserved almost 100% of activity. In contrast, free enzymes retained no more than 20% of their original activities at the same condition. This study shows the extraordinary protecting effect of MOF shell on increasing enzyme stability at extremely harsh conditions. The enzyme immobilized in MOF exhibited enhanced thermal stability and high tolerance towards protein denaturing organic solvents.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Researcher 12 18%
Student > Master 11 16%
Student > Bachelor 7 10%
Lecturer 4 6%
Other 8 12%
Unknown 8 12%
Readers by discipline Count As %
Chemistry 25 37%
Chemical Engineering 9 13%
Biochemistry, Genetics and Molecular Biology 9 13%
Agricultural and Biological Sciences 4 6%
Engineering 4 6%
Other 7 10%
Unknown 9 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2017.
All research outputs
#10,059,262
of 11,342,318 outputs
Outputs from Bioresources and Bioprocessing
#30
of 36 outputs
Outputs of similar age
#223,124
of 267,591 outputs
Outputs of similar age from Bioresources and Bioprocessing
#1
of 2 outputs
Altmetric has tracked 11,342,318 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 36 research outputs from this source. They receive a mean Attention Score of 2.8. This one scored the same or higher as 6 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,591 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them