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A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths

Overview of attention for article published in Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, January 2014
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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4 tweeters

Citations

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36 Dimensions

Readers on

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30 Mendeley
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Title
A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths
Published in
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, January 2014
DOI 10.1002/jez.b.22559
Pubmed ID
Authors

Pierre Boudinot, Jun Zou, Tatsuya Ota, Francesco Buonocore, Giuseppe Scapigliati, Adriana Canapa, John Cannon, Gary Litman, John D. Hansen

Abstract

The recent availability of both robust transcriptome and genome resources for coelacanth (Latimeria chalumnae) has led to unique discoveries for coelacanth immunity such as the lack of IgM, a central component of adaptive immunity. This study was designed to more precisely address the origins and evolution of gene families involved in the initial recognition and response to microbial pathogens, which effect innate immunity. Several multigene families involved in innate immunity are addressed, including: Toll-like receptors (TLRs), retinoic acid inducible gene 1 (RIG1)-like receptors (RLRs), the nucleotide-binding domain and leucine-rich repeat containing proteins (NLRs), diverse immunoglobulin domain-containing proteins (DICP) and modular domain immune-type receptors (MDIRs). Our analyses also include the tripartite motif-containing proteins (TRIM), which are involved in pathogen recognition as well as the positive regulation of antiviral immunity. Finally, this study addressed some of the downstream effectors of the antimicrobial response including IL-1 family members, type I and II interferons (IFN) and IFN-stimulated effectors (ISGs). Collectively, the genes and gene families in coelacanth that effect innate immune functions share characteristics both in content, structure and arrangement with those found in tetrapods but not in teleosts. The findings support the sister group relationship of coelacanth fish with tetrapods. J. Exp. Zool. (Mol. Dev. Evol.) 9999B: 1-22, 2014. © 2014 Wiley Periodicals, Inc.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 37%
Researcher 6 20%
Student > Master 4 13%
Unspecified 3 10%
Other 2 7%
Other 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 67%
Unspecified 4 13%
Immunology and Microbiology 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2015.
All research outputs
#7,227,595
of 12,522,668 outputs
Outputs from Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
#181
of 315 outputs
Outputs of similar age
#105,314
of 238,794 outputs
Outputs of similar age from Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
#3
of 10 outputs
Altmetric has tracked 12,522,668 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 315 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.