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Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease

Overview of attention for article published in BMC Neuroscience, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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2 tweeters

Citations

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23 Dimensions

Readers on

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50 Mendeley
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Title
Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
Published in
BMC Neuroscience, January 2014
DOI 10.1186/1471-2202-15-21
Pubmed ID
Authors

Krithika Muthukumaran, Samantha Leahy, Kate Harrison, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Corrine Keshan, Daniel Lopatin, Harvey Miller, Henryk Borowy-Borowski, Patricia Lanthier, Shelly Weinstock, Siyaram Pandey

Abstract

Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson's disease (PD). Paraquat interacts with cellular redox systems and causes mitochondrial dysfunction and the formation of reactive oxygen species, which in turn, plays a crucial role in the pathophysiology of PD. Various antioxidant therapies have been explored with the expectations that they deliver health benefits to the PD patients, however, no such therapies were effective. Here we have tested the neuroprotective efficacy of a novel water-soluble CoQ10 (Ubisol-Q10), in a rat model of paraquat-induced neurodegeneration in order to evaluate its potential application in the management of PD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
United States 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 20%
Researcher 7 14%
Student > Master 6 12%
Other 5 10%
Student > Ph. D. Student 5 10%
Other 12 24%
Unknown 5 10%
Readers by discipline Count As %
Medicine and Dentistry 11 22%
Agricultural and Biological Sciences 10 20%
Pharmacology, Toxicology and Pharmaceutical Science 6 12%
Neuroscience 5 10%
Biochemistry, Genetics and Molecular Biology 5 10%
Other 4 8%
Unknown 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2014.
All research outputs
#1,783,962
of 4,507,509 outputs
Outputs from BMC Neuroscience
#229
of 640 outputs
Outputs of similar age
#41,990
of 123,798 outputs
Outputs of similar age from BMC Neuroscience
#13
of 39 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 640 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,798 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.