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The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron

Overview of attention for article published in PLOS ONE, December 2012
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  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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1 X user
facebook
1 Facebook page
wikipedia
9 Wikipedia pages

Citations

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60 Dimensions

Readers on

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105 Mendeley
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2 CiteULike
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Title
The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
Published in
PLOS ONE, December 2012
DOI 10.1371/journal.pone.0051169
Pubmed ID
Authors

Michael D. Forrest, Mark J. Wall, Daniel A. Press, Jianfeng Feng

Abstract

In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 2 2%
United Kingdom 2 2%
Germany 1 <1%
Brazil 1 <1%
Uruguay 1 <1%
Australia 1 <1%
Canada 1 <1%
Unknown 96 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 30%
Researcher 18 17%
Student > Bachelor 13 12%
Student > Master 10 10%
Student > Postgraduate 6 6%
Other 13 12%
Unknown 13 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 30%
Neuroscience 25 24%
Biochemistry, Genetics and Molecular Biology 6 6%
Physics and Astronomy 6 6%
Engineering 6 6%
Other 14 13%
Unknown 16 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2023.
All research outputs
#6,503,129
of 23,467,261 outputs
Outputs from PLOS ONE
#80,998
of 200,904 outputs
Outputs of similar age
#68,221
of 284,125 outputs
Outputs of similar age from PLOS ONE
#1,514
of 4,872 outputs
Altmetric has tracked 23,467,261 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 200,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 4,872 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.