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Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

Overview of attention for article published in Journal of Translational Medicine, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
4 tweeters
patent
9 patents

Citations

dimensions_citation
111 Dimensions

Readers on

mendeley
168 Mendeley
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Title
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
Published in
Journal of Translational Medicine, January 2014
DOI 10.1186/1479-5876-12-36
Pubmed ID
Authors

Lei Lu, Xiaobing Xu, Bin Zhang, Rongsheng Zhang, Hongzan Ji, Xuan Wang

Abstract

The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated on activated T cells and increases their proliferation, activation and cytokine production. We hypothesize that concomitant PD-1 blockade and GITR triggering would synergistically improve the effector functions of tumor-infiltrating T cells and increase the antitumor immunity. In present study, we evaluated the antitumor effects and mechanisms of combined PD-1 blockade and GITR triggering in a clinically highly relevant murine ID8 ovarian cancer model.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Uruguay 1 <1%
France 1 <1%
Belgium 1 <1%
Netherlands 1 <1%
Unknown 161 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 51 30%
Student > Ph. D. Student 34 20%
Student > Master 21 13%
Other 17 10%
Student > Doctoral Student 7 4%
Other 22 13%
Unknown 16 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 30%
Medicine and Dentistry 38 23%
Immunology and Microbiology 22 13%
Biochemistry, Genetics and Molecular Biology 17 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 13 8%
Unknown 23 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2021.
All research outputs
#1,687,317
of 17,864,600 outputs
Outputs from Journal of Translational Medicine
#259
of 3,273 outputs
Outputs of similar age
#24,889
of 266,282 outputs
Outputs of similar age from Journal of Translational Medicine
#11
of 213 outputs
Altmetric has tracked 17,864,600 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,273 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 213 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.