Title |
Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)
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Published in |
Journal of Medicinal Food, June 2017
|
DOI | 10.1089/jmf.2016.0176 |
Pubmed ID | |
Authors |
Marina Kolundžić, Tatjana Stanojković, Jelena Radović, Ana Tačić, Margarita Dodevska, Marina Milenković, Francesca Sisto, Carla Masia, Giampietro Farronato, Vesna Nikolić, Tatjana Kundaković |
Abstract |
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 μg/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 ± 1.24-134.79 ± 0.01 μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, β-glucans, and polyphenolic compounds. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 21% |
Student > Master | 7 | 21% |
Student > Ph. D. Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Professor | 1 | 3% |
Other | 3 | 9% |
Unknown | 9 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Agricultural and Biological Sciences | 4 | 12% |
Medicine and Dentistry | 4 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Other | 6 | 18% |
Unknown | 9 | 27% |