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Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis.

Overview of attention for article published in Nature Communications, February 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
4 tweeters
f1000
1 research highlight platform

Citations

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25 Dimensions

Readers on

mendeley
59 Mendeley
Title
Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis.
Published in
Nature Communications, February 2014
DOI 10.1038/ncomms4177
Pubmed ID
Authors

Shaun M. Davis, Amanda L. Thomas, Krystle J. Nomie, Longwen Huang, Herman A. Dierick

Abstract

Aggressive behaviour is widespread throughout the animal kingdom. However, its mechanisms are poorly understood, and the degree of molecular conservation between distantly related species is unknown. Here we show that knockdown of tailless (tll) increases aggression in Drosophila, similar to the effect of its mouse orthologue Nr2e1. Tll localizes to the adult pars intercerebralis (PI), which shows similarity to the mammalian hypothalamus. Knockdown of tll in the PI is sufficient to increase aggression and is rescued by co-expressing human NR2E1. Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI. In addition, genetically activating PI neurons increases aggression, mimicking the aggression-inducing effect of hypothalamic stimulation. Together, our results suggest that a transcriptional control module regulates neuropeptide signalling from the neurosecretory cells of the brain to control aggressive behaviour.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Portugal 1 2%
France 1 2%
Canada 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 42%
Researcher 15 25%
Student > Bachelor 9 15%
Student > Master 3 5%
Student > Postgraduate 2 3%
Other 3 5%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 68%
Neuroscience 10 17%
Biochemistry, Genetics and Molecular Biology 3 5%
Immunology and Microbiology 1 2%
Sports and Recreations 1 2%
Other 1 2%
Unknown 3 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2014.
All research outputs
#6,442,605
of 12,394,774 outputs
Outputs from Nature Communications
#15,162
of 20,494 outputs
Outputs of similar age
#84,859
of 231,231 outputs
Outputs of similar age from Nature Communications
#330
of 555 outputs
Altmetric has tracked 12,394,774 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,494 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,231 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 555 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.