Title |
Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer’s disease-relevant murine model
|
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Published in |
BMC Neuroscience, February 2014
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DOI | 10.1186/1471-2202-15-24 |
Pubmed ID | |
Authors |
Rosemary A Schuh, Kathryn C Jackson, Anna E Schlappal, Espen E Spangenburg, Christopher W Ward, Ji H Park, Natalie Dugger, Guo Li Shi, Paul S Fishman |
Abstract |
Age is considered a primary risk factor for neurodegenerative diseases including Alzheimer's disease (AD). It is also now well understood that mitochondrial function declines with age. Mitochondrial deficits have been previously assessed in brain from both human autopsy tissue and disease-relevant transgenic mice. Recently it has been recognized that abnormalities of muscle may be an intrinsic aspect of AD and might contribute to the pathophysiology. However, deficits in mitochondrial function have yet to be clearly assessed in tissues outside the central nervous system (CNS). In the present study, we utilized a well-characterized AD-relevant transgenic mouse strain to assess mitochondrial respiratory deficits in both brain and muscle. In addition to mitochondrial function, we assessed levels of transgene-derived amyloid precursor protein (APP) in homogenates isolated from brain and muscle of these AD-relevant animals. |
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Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Spain | 1 | 2% |
Germany | 1 | 2% |
Unknown | 48 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 21% |
Professor | 7 | 13% |
Student > Ph. D. Student | 5 | 10% |
Professor > Associate Professor | 5 | 10% |
Student > Master | 5 | 10% |
Other | 17 | 33% |
Unknown | 2 | 4% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 23% |
Medicine and Dentistry | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Neuroscience | 6 | 12% |
Nursing and Health Professions | 3 | 6% |
Other | 7 | 13% |
Unknown | 6 | 12% |