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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
|
|---|---|
| Published in |
European Heart Journal, June 2017
|
| DOI | 10.1093/eurheartj/ehx260 |
| Pubmed ID | |
| Authors |
Christine Landlinger, Marianne G. Pouwer, Claudia Juno, José W.A. van der Hoorn, Elsbet J. Pieterman, J. Wouter Jukema, Guenther Staffler, Hans M.G. Princen, Gergana Galabova |
| Abstract |
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target for the treatment of hypercholesterolaemia and atherosclerosis. PCSK9 binds to the low density lipoprotein receptor and enhances its degradation, which leads to the reduced clearance of low density lipoprotein cholesterol (LDLc) and a higher risk of atherosclerosis. In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coronary heart disease in the atherogenic APOE*3Leiden.CETP mouse model. Control and AT04A vaccine-treated mice were fed western-type diet for 18 weeks. Antibody titres, plasma lipids, and inflammatory markers were monitored by ELISA, FPLC, and multiplexed immunoassay, respectively. The progression of atherosclerosis was evaluated by histological analysis of serial cross-sections from the aortic sinus. The AT04A vaccine induced high and persistent antibody levels against PCSK9, causing a significant reduction in plasma total cholesterol (-53%, P < 0.001) and LDLc compared with controls. Plasma inflammatory markers such as serum amyloid A (SAA), macrophage inflammatory protein-1β (MIP-1β/CCL4), macrophage-derived chemokine (MDC/CCL22), cytokine stem cell factor (SCF), and vascular endothelial growth factor A (VEGF-A) were significantly diminished in AT04A-treated mice. As a consequence, treatment with the AT04A vaccine resulted in a decrease in atherosclerotic lesion area (-64%, P = 0.004) and aortic inflammation as well as in more lesion-free aortic segments (+119%, P = 0.026), compared with control. AT04A vaccine induces an effective immune response against PCSK9 in APOE*3Leiden.CETP mice, leading to a significant reduction of plasma lipids, systemic and vascular inflammation, and atherosclerotic lesions in the aorta. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 20% |
| United Kingdom | 8 | 14% |
| Spain | 6 | 10% |
| Brazil | 2 | 3% |
| Finland | 2 | 3% |
| Netherlands | 2 | 3% |
| France | 2 | 3% |
| Canada | 2 | 3% |
| Sweden | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 18 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 58% |
| Scientists | 15 | 25% |
| Practitioners (doctors, other healthcare professionals) | 7 | 12% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Unknown | 145 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 14% |
| Student > Ph. D. Student | 18 | 12% |
| Researcher | 18 | 12% |
| Student > Master | 12 | 8% |
| Other | 8 | 5% |
| Other | 20 | 14% |
| Unknown | 50 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 23% |
| Biochemistry, Genetics and Molecular Biology | 19 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 8% |
| Agricultural and Biological Sciences | 9 | 6% |
| Immunology and Microbiology | 9 | 6% |
| Other | 8 | 5% |
| Unknown | 55 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 498. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2018.
All research outputs
#52,338
of 25,455,127 outputs
Outputs from European Heart Journal
#113
of 11,076 outputs
Outputs of similar age
#1,095
of 329,937 outputs
Outputs of similar age from European Heart Journal
#4
of 182 outputs
Altmetric has tracked 25,455,127 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,076 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.