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The performance of serological tests for Leishmania infantum infection screening in dogs depends on the prevalence of the disease

Overview of attention for article published in Revista do Instituto de Medicina Tropical de São Paulo, January 2017
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Title
The performance of serological tests for Leishmania infantum infection screening in dogs depends on the prevalence of the disease
Published in
Revista do Instituto de Medicina Tropical de São Paulo, January 2017
DOI 10.1590/s1678-9946201759039
Pubmed ID
Authors

Ivete Lopes de Mendonça, Joilson Ferreira Batista, Henk Schallig, Maria do Socorro Pires e Cruz, Diego Peres Alonso, Paulo Eduardo Martins Ribolla, Dorcas Lamounier Costa, Carlos Henrique Nery Costa

Abstract

Dogs are considered the main reservoir of Leishmania infantum. This protozoan causes visceral leishmaniasis (VL), an uncontrolled urban zoonosis in Brazil. Serological tests and polymerase chain reaction (PCR) on peripheral blood were performed to identify infected dogs in scenarios of higher and lower prevalence of the disease (Teresina and Vitória). One-hundred infected and 57 non-infected animals from Teresina and 100 non-infected animals from Vitória were studied. Animal selection was not dependent on previous serology. The sensitivity (Teresina) and specificity (Teresina and Vitória) were as follows: indirect antibody fluorescence (IFAT) cut-off of 1:40 (IFAT 1:40): 96%, 18%, and 76%; IFAT 1:80: 90%, 33%, and 93%; direct agglutination test (DAT): 96%, 33%, and 98%; fast agglutination screening test (FAST): 93%, 68%, and 100%; immunochromatographic assay with a recombinant rK39 antigen (rK39): 88%, 74%, and 98%; enzyme linked immunosorbent assay (ELISA): 91%, 79%, and 98%; rapid dual-path platform test (TR DPP®): 98%, 60%, and 98%; and blood PCR: 29%, 93%, and 97%, respectively. In the high transmission area, none of the tests adequately discriminated L. infantum-infected from non-infected dogs. However, in the high transmission city, the area under the receiver operating characteristic (ROC) curve of FAST, DAT, ICrK39, ELISA and TR DPP® was high.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 19%
Researcher 10 14%
Student > Ph. D. Student 7 10%
Student > Doctoral Student 6 8%
Student > Bachelor 5 7%
Other 10 14%
Unknown 21 29%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 15 21%
Agricultural and Biological Sciences 8 11%
Medicine and Dentistry 6 8%
Immunology and Microbiology 6 8%
Biochemistry, Genetics and Molecular Biology 5 7%
Other 8 11%
Unknown 25 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#10,109,672
of 11,400,239 outputs
Outputs from Revista do Instituto de Medicina Tropical de São Paulo
#209
of 241 outputs
Outputs of similar age
#219,934
of 263,056 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de São Paulo
#1
of 1 outputs
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So far Altmetric has tracked 241 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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